Solid self-emulsifying drug delivery system of Furosemide

Abstract

The aim of the present investigation was to prepare and optimize solid self-emulsifying drug delivery system (S-SEDDS) of Furosemide, which is poorly water soluble drug. Solubility of furosemide was performed in different oils, surfactants, co-surfactants and co-solvents. Selection of these ingredients in liquid Self Emulsifying Formulation was done on the bases of solubility and pseudo ternary phase diagram. The selected ingredients were - Capmul MCM C8 was as oil which also has properties of co-surfactants, Tween 80 as surfactant and PEG 400 as co-solvent. Prepared liquid Self Emulsifying Formulation was converted in to solid powder with the help of PEG 6000, micro crystalline cellulose PH 102. The solid powder with liquid SEF was compressed into tablet & prepared tablets were evaluated for different pre-compression, post compression evaluation parameters. The formula for tablet was optimized by using 32 factorial design. The results of in-vitro drug release data of optimized batch showed drastically improved dissolution rate of Furosemide. The results of accelerated stability study of optimized batch indicated that the optimized formulation was stable