Page Header Logo
TEI of Athens eJournals

Determination of cilazapril in micrograms concentration using spectrophotometry

Sridevi Neelam, Chennupati Srilakshmi, Chandra Bala Sekharan

Abstract


A simple, sensitive and economical spectrophotometric method was developed for the determination of cilazapril in bulk and tablet forms. The method is based on the bromination of cilazapril by the bromine generated by the action of the HCl on the bromate–bromide mixture followed by the reaction of unreacted bromine with a fixed concentration of methyl orange and measuring the absorbance at 530 nm. The absorbance-concentration plot was linear over the range 0.4–6 µg/ml with regression coefficient value of 0.9996. The limits of detection and quantitation were 0.0126 µg/ml and 0.0381 µg/ml, respectively. The method was successfully applied to tablet dosage forms. The recovery results obtained by the proposed method for the tablets dosage form were statistically compared with those of the official method by applying Student's t- and F-test. No significant difference was observed between the proposed and official methods


Keywords


Cilazapril, bromate–bromide mixture, methyl orange, tablet, analysis

Full Text: PDF

DOI: 10.18780/e-jst.v11i2.3099

Refbacks

  • There are currently no refbacks.

The application for presenting electronic journals TEI developed within subproject 2 "electronic publishing service" the Act "Development Services Digital Library of TEI" and financed by the operational program "Digital Convergence", NSRF 2007-2013.